首页|补体系统参与病理性疼痛的机制研究进展

补体系统参与病理性疼痛的机制研究进展

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Progress in mechanism of complement system involved in pathological pain
The complement system comprises intrinsic complement components,complement regulatory pro-teins,and complement receptors.Complement activation plays a role in promoting the sensitization of peripheral pain re-ceptors,enhancing immune cell activity,and participating in the regulation of axon regeneration after nerve injury.The in-teraction of the complement system contributes to the development and maintenance of pathological pain,affecting the dor-sal root ganglion neurons,spinal dorsal horn,and brain.Consequently,targeting the complement system holds promise as a therapeutic approach for neuropathic pain treatment.This paper reviews the progress in understanding the functions of the complement system and its implications in pathological pain,offering valuable insights for the future development of targeted drug therapies.

complement systempathological painspinal corddorsal root ganglioninflammation

骆延、梁璇、慕静然、徐陶、曾俊伟

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遵义医科大学生理学教研室,贵州 遵义 563000

补体系统 病理性疼痛 脊髓 背根神经节 炎症

国家自然科学基金资助项目贵州省教育厅创新群体重大研究项目

31860291黔教合KY字[2018]025号

2024

中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCD北大核心
影响因子:1.065
ISSN:1000-4718
年,卷(期):2024.40(2)
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