沉默信息调节因子3通过调节线粒体功能障碍减轻特发性肺纤维化的研究进展
Progress in role of silent information regulator 3 in improving idiopathic pulmonary fibrosis by regulating mitochondrial dysfunction
杨树森 1刘禹杉 1张仪霖 1惠毅 1李京涛 2闫曙光3
作者信息
- 1. 陕西中医药大学基础医学院,陕西 咸阳 712046
- 2. 陕西中医药大学附属医院,陕西 咸阳 712000
- 3. 陕西中医药大学基础医学院,陕西 咸阳 712046;陕西省胃肠病证方药重点研究室,陕西 咸阳 712046
- 折叠
Abstract
Idiopathic pulmonary fibrosis(IPF)is a chronic progressive interstitial lung disease of unknown etiology,with a rapid disease course,poor prognosis,and the absence of effective therapeutic drugs.Mitochondrial dys-function is one of the crucial causes of inducing IPF.Silent information regulator 3(SIRT3)can restore mitochondrial ho-meostasis by inhibiting mitochondrial oxidative stress,repairing mitochondrial DNA damage,and ameliorating abnormal mitochondrial lipid metabolism.This paper summarizes the role and mechanism of SIRT3 in attenuating mitochondrial dys-function based on delineating the relationship between mitochondrial dysfunction and IPF,aiming to provide references for finding effective treatment methods for IPF.
关键词
特发性肺纤维化/线粒体功能障碍/沉默信息调节因子3/DNA损伤/脂质代谢Key words
idiopathic pulmonary fibrosis/mitochondrial dysfunction/silent information regulator 3/DNA damage/lipid metabolism引用本文复制引用
基金项目
国家自然科学基金资助项目(81703974)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据