中国病理生理杂志2024,Vol.40Issue(3) :551-556.DOI:10.3969/j.issn.1000-4718.2023.00.004

神经胶质细胞钙信号对缺血性脑卒中所致神经功能损伤的影响

Effect of neuroglial calcium signaling on neurological impairment in ischemic stroke

陈钰洁 王磊 郑晨
中国病理生理杂志2024,Vol.40Issue(3) :551-556.DOI:10.3969/j.issn.1000-4718.2023.00.004

神经胶质细胞钙信号对缺血性脑卒中所致神经功能损伤的影响

Effect of neuroglial calcium signaling on neurological impairment in ischemic stroke

陈钰洁 1王磊 1郑晨1
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作者信息

  • 1. 遵义医科大学珠海校区生理学教研室,广东 珠海 519041
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Abstract

Stroke is one of the leading causes of disability and death in China,but its mechanism has not been thoroughly elucidated.As an important class of cells in maintaining neurological homeostasis,the intracellular calcium signaling of glial cells plays a dual role in mitigating and exacerbating neuronal damage in stroke and largely determines the progression and outcome of stroke.In this review of the literature,focusing on astrocytes,which account for the largest proportion of glial cells,we review the mechanism of glial calcium signaling after stroke and its effect on post-stroke neuro-logical function,to provide reference for post-stroke neuroprotection and repair.

关键词

神经胶质细胞/星形胶质细胞/钙信号/缺血性脑卒中

Key words

neuroglia/astrocyte/calcium signaling/ischemic stroke

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基金项目

国家自然科学基金(81860230)

出版年

2024
中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCDCSCD北大核心
影响因子:1.065
ISSN:1000-4718
参考文献量51
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