Advances in regulation of disease development by protein lactylation modifications
Known as a classic product of glucose metabolism,lactic acid has been regarded as a metabolic waste.However,it wasn't until the discovery of Warburg effect in tumors that researchers refocused on the role of lactic acid in cells.Being a kind of signaling molecule with multiple functions,lactic acid is a key metabolic product connecting gly-colysis and oxidative phosphorylation,and it also has non-metabolic activity.Recent studies have shown that lactic acid can be used as a substrate to participate in a novel post-translational modification of proteins,known as protein lactylation.It can be involved in many kinds of diseases,and plays an important role in immune regulation and homeostasis mainte-nance.This paper briefly describes and summarizes the important role of lactylation modification in the developmental mecha-nisms of diseases such as tumors,inflammation,neuropsychiatric diseases,cardiocerebrovascular diseases,and so on.
国家科技期刊平台
NSTL
万方数据
维普
