Progress in role of ferroptosis in multiple myeloma
Multiple myeloma(MM)is an incurable hematological malignancy characterized by the prolifera-tion of clonal plasma cells.High relapse rate and acquired drug resistance remain key challenges for MM.Therefore,it is necessary to find new therapeutic targets and prognostic biomarkers for MM.Ferroptosis is a new type of iron-dependent programmed cell death,which can inhibit tumor.Recent studies have suggested that targeted induction of ferroptosis in MM cells through iron metabolism,lipid metabolism and other pathways can effectively inhibit the growth and proliferation of MM cells.In addition,ferroptosis-related genes are of great significance for the prognosis of MM.This review summariz-es the progress of ferroptosis in MM.
国家科技期刊平台
NSTL
万方数据
维普
