Abstract
Multiple myeloma(MM)is an incurable hematological malignancy characterized by the prolifera-tion of clonal plasma cells.High relapse rate and acquired drug resistance remain key challenges for MM.Therefore,it is necessary to find new therapeutic targets and prognostic biomarkers for MM.Ferroptosis is a new type of iron-dependent programmed cell death,which can inhibit tumor.Recent studies have suggested that targeted induction of ferroptosis in MM cells through iron metabolism,lipid metabolism and other pathways can effectively inhibit the growth and proliferation of MM cells.In addition,ferroptosis-related genes are of great significance for the prognosis of MM.This review summariz-es the progress of ferroptosis in MM.
基金项目
浙江省自然科学基金(LBY23H080002)
浙江省医药卫生科技计划(2023KY348)
浙江省卫生高层次人才创新人才项目(浙卫办[2022]32号)
国家科技期刊平台
NSTL
维普
万方数据