细胞外基质:毒蛇咬伤致局部组织损伤的治疗新靶点
Extracellular matrix:a new therapeutic target for local tissue damage caused by snake bites
李玉梅 1杨悦 2易军 3严张仁 3王万春 3董德刚2
作者信息
- 1. 江西中医药大学研究生院,江西 南昌 330004
- 2. 江西中医药大学中医学院,江西 南昌 330004
- 3. 江西中医药大学附属医院中医外科,江西 南昌 330006
- 折叠
摘要
毒蛇咬伤具有发病急、病情变化迅速、致残率及死亡率高等特点.毒素螯入对人体的影响分为全身性和局部毒化作用,目前抗蛇毒血清的普及大大降低了毒蛇咬伤的死亡率,但局部组织损伤及遗留的永久性功能障碍仍是亟待解决的问题.研究发现,蛇毒金属蛋白酶、透明质酸酶、磷脂酶等毒素通过干扰细胞外基质(ECM)的降解和重塑参与多种局部病理效应的发生.本文对ECM与毒蛇咬伤局部组织损伤发展过程的相关机制进行综述,以期寻找有效的治疗靶点,为毒蛇咬伤所致局部组织损伤的临床研究和防治工作提供参考和思路.
Abstract
Snake bites are characterized by acute onset,rapid changes in condition,and high disability and mortality rates.The effects of snake venom on the human body are divided into systemic and local toxic effects.The popu-larity of antivenom has greatly reduced the mortality of snake bites,but local tissue damage and permanent dysfunction are still problems to be solved urgently.Studies have found that snake venom metalloproteinases,hyaluronidases,phospholi-pases and other venoms participate in a variety of local pathological effects by interfering with the degradation and remodel-ing of extracellular matrix(ECM).This article reviews the mechanism of ECM in the development of local tissue damage caused by snake bites,in order to find effective therapeutic targets and provide reference and ideas for the clinical research and prevention of local tissue damage caused by snake bites.
关键词
毒蛇咬伤/细胞外基质/局部组织损伤/出血/肌毒性Key words
snake bites/extracellular matrix/local tissue damage/hemorrhage/myotoxicity引用本文复制引用
基金项目
国家自然科学基金地区项目(81360288)
国家自然科学基金地区项目(81960874)
国家自然科学基金地区项目(82260937)
江西省自然科学基金重点项目(20202ACB206010)
江西省2023年度研究生创新专项资金项目(YC2023-B230)
江西中医药大学首批科技创新团队资助项目(CXTD22009)
出版年
2024
国家科技期刊平台
NSTL
万方数据