lncRNA在肌少-骨质疏松症中作用机制的研究进展
Progress in mechanism of lncRNA in osteo-sarcopenia
刘晏东 1邓强 2彭冉东2
作者信息
- 1. 甘肃中医药大学,甘肃 兰州 730000
- 2. 甘肃省中医院,甘肃 兰州 730050
- 折叠
摘要
肌少-骨质疏松症是指骨骼肌与骨骼同时发生代谢性衰减病变,该病的发生与发展过程涉及多因素、多基因的复杂调控网络.长链非编码RNA作为一类重要的非编码RNA分子,在调控功能基因的表达中发挥着重要的调节作用.由于长链非编码RNA也可通过同时调控肌细胞和骨细胞的增殖、分化、死亡及相互作用以影响肌肉、骨骼系统的代谢和重建,可成为改善肌少-骨质疏松症的一个新机制和新靶点.
Abstract
Osteoporosis due to muscle deficiency refers to the simultaneous occurrence of metabolic attenua-tion lesions in both skeletal muscle and bone.The occurrence and development of this disease involve a complex regulato-ry network of multiple factors and genes.Long noncoding RNA(lncRNA),as an important class of noncoding RNA mole-cules,plays an important regulatory role in regulating the expression of functional genes.Due to the fact that lncRNA can also affect the metabolism and reconstruction of muscle and skeletal systems by simultaneously regulating the proliferation,differentiation,death,and interaction of muscle and bone cells,they can become a new mechanism and target for improv-ing sarcopenia osteoporosis.
关键词
肌少-骨质疏松症/长链非编码RNA/肌骨串扰Key words
osteo-sarcopenia/long noncoding RNA/muscle-bone crosstalk引用本文复制引用
基金项目
国家中医药管理局国家中医临床研究基地业务建设科研专项课题项目(JDZX2015039)
甘肃省联合科研基金项目(23JRRA1534)
兰州市科技计划项目(2022-3-30)
出版年
2024
国家科技期刊平台
NSTL
万方数据