Ras相关C3肉毒杆菌毒素底物1在肺部疾病中作用及机制的研究进展
Advances in role and mechanisms of Ras-related C3 botulinum toxin sub-strate 1 in pulmonary diseases
许文霞 1方育1
作者信息
- 1. 昆明医科大学第一附属医院麻醉科,云南 昆明 650000
- 折叠
摘要
Ras相关C3肉毒杆菌毒素底物1(Ras-related C3 botulinum toxin substrate 1,RAC1)是Ras GTPase超家族的重要成员,在细胞的运动、增殖、黏附等方面发挥核心作用,同时还参与调节血管通透性以及细胞屏障功能.近年来,RAC1在多种肺部疾病发生、发展过程的作用逐渐受到关注,并逐渐成为肺部疾病研究的新方向.本文系统阐述了RAC1的生物学特性并总结了其在肺肿瘤、慢性阻塞性肺疾病、肺损伤和动脉型肺动脉高压中的功能及分子机制,以期为肺部疾病的治疗提供新思路.
Abstract
Ras-related C3 botulinum toxin substrate 1(RAC1)is a crucial member of the Ras GTPase super-family,exerting an overriding role in cell behaviors such as motility,proliferation and adhesion,and is involved in regu-lating vascular permeability and cellular barrier function.Recently,the significance of RAC1 in the etiology and progres-sion of various pulmonary disorders has garnered increasing attention,which sheds light on lung disease study.In this re-view,we introduce the characteristics of RAC1 systematically and recapitulate its effects and molecular mechanisms in the context of lung tumors,chronic obstructive pulmonary disease,lung injury and pulmonary arterial hypertension,hoping to provide new insights for future pulmonary disease treatment.
关键词
Ras相关C3肉毒杆菌毒素底物1/肺癌/慢性阻塞性肺疾病/肺损伤/动脉型肺动脉高压Key words
Ras-related C3 botulinum toxin substrate 1/lung cancer/chronic obstructive pulmonary dis-ease/lung injury/pulmonary arterial hypertension引用本文复制引用
基金项目
云南省科技厅昆明医科大学应用基础联合专项(202101AY070001-133)
出版年
2024
国家科技期刊平台
NSTL
万方数据