Metrnl在糖尿病及其新兴并发症中作用机制的研究进展
Advances in mechanism of Metrnl in diabetes mellitus and its emerging complications
杨钟铭 1贾珏 1邓霞 1杨玲1
作者信息
- 1. 江苏大学附属医院内分泌代谢科,江苏 镇江 212000
- 折叠
摘要
近年来糖尿病的发病率呈上升趋势,但目前的治疗方案有限.随着患者预期寿命的延长,出现了一系列糖尿病新兴并发症.镍纹蛋白样蛋白(Meteorin-like protein,Metrnl)是一种新型脂肪因子.研究表明其与糖脂代谢、肿瘤生长、免疫、认知功能、骨骼肌修复、心脑血管功能密切相关,并参与糖尿病及其新兴并发症的发生发展.本文就目前Metrnl在肿瘤、感染、肝病、认知功能和失能中的作用及机制进行阐述.
Abstract
Recently,the incidence of diabetes mellitus has been increasing;however,current treatment op-tions are limited.As the life expectancy of patients has increased,a range of diabetes mellitus-associated complications with have emerged.Meteorin-like protein(Metrnl)is a novel adipokine closely related to glucose and lipid metabolism,tumor growth,immunity,cognitive function,skeletal muscle repair,and cardiovascular and cerebrovascular functions and involved in the occurrence and development of diabetes mellitus and emerging complications.This study focuses on the current roles and mechanisms of Metrnl in cancer,infections,liver diseases,cognitive function,and disabilities.
关键词
Metrnl蛋白/葡萄糖摄取/胰岛素抵抗/糖尿病新兴并发症Key words
Metrnl protein/glucose uptake/insulin resistance/emerging complications of diabetes mellitus引用本文复制引用
基金项目
镇江市重点研发计划(社会发展)(SH2023016)
出版年
2024
国家科技期刊平台
NSTL
万方数据