高脂饮食对阿尔茨海默病病变的影响及小胶质细胞在其中的作用
Effects of high-fat diet on pathology of Alzheimer disease and role of mi-croglia in this process
任晶 1谭超杰 1邹文奇 1刘静颐 1盛瑜1
作者信息
- 1. 北华大学药学院,吉林 吉林 132013
- 折叠
摘要
阿尔茨海默病(Alzheimer disease,AD)病程漫长,本文从AD经典病理事件时间线出发,以小胶质细胞异常激活为桥梁,以期明确AD病理事件出现时间的先后顺序.脂质代谢异常与小胶质细胞功能异常、AD病理改变密切相关,以此为介入点,本文综述了短、长期高脂饮食对AD病变发展的影响及其可能的机制,以期为AD的早期介入提供思路.
Abstract
Due to the long pathological process of Alzheimer disease(AD),this paper begins with the time-line of classical pathological events in AD and uses anomalous microglia activation as a starting point to elucidate the role of abnormal lipid metabolism in the pathological process of AD.This includes its influence on microglial pathology and its interactions with the two primary nodes of AD,namely,Amyloid-β and the microtubule-associated protein tau.Using this as a foundation,the paper briefly describes the effects of abnormal lipid metabolism caused by short-term and long-term high-fat diets on the pathological progression of AD and its potential mechanisms,aiming to provide a reference framework for the early intervention of AD.
关键词
阿尔茨海默病/高脂饮食/小胶质细胞/脂质代谢Key words
Alzheimer disease/high-fat diet/microglia/lipid metabolism引用本文复制引用
基金项目
国家自然科学基金青年基金(82004067)
吉林省中医药科技项目(2022080)
出版年
2024
国家科技期刊平台
NSTL
万方数据