T细胞耗竭的研究进展
Research progress in T-cell exhaustion
张月霞 1潘耀柱2
作者信息
- 1. 青海大学研究生院,青海 西宁 810000;中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730000
- 2. 中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730000
- 折叠
摘要
T细胞耗竭指慢性感染和肿瘤患者体内T细胞功能的丧失.由于较长时间暴露于持续性抗原等炎症信号,T细胞逐渐失去效应功能,记忆T细胞特征也开始缺失.耗竭T细胞会影响肿瘤预后及病毒转归,耗竭的严重程度更会对肿瘤的预后带来一系列不良影响.随着肿瘤免疫治疗的广泛开展,深入理解T细胞耗竭机制以及通过逆转T细胞耗竭优化肿瘤免疫治疗方案已成为当前研究的热点.本文就T细胞耗竭发生机制、耗竭T细胞特征以及耗竭状态的逆转作一综述.
Abstract
T-cell exhaustion is the loss of T-cell function in patients with chronic infections and cancer.Pro-longed exposure to inflammatory signals or persistent antigens causes T cells to gradually lose their effector function and memory characteristics.Exhausted T cells affect cancer prognosis and the outcome of viral infection,and the severity of ex-haustion has a range of adverse effects on cancer prognosis.The extensive development of tumor immunotherapy has driven current research to understand the mechanism of T-cell exhaustion as well as to optimize tumor immunotherapy regimens by reversing T-cell exhaustion.This article reviews the mechanism of T-cell exhaustion,the characteristics of exhausted T cells,and the reversal of T-cell exhaustion status.
关键词
T细胞耗竭/抑制性受体/细胞因子/免疫治疗Key words
T-cell exhaustion/inhibitory receptor/cytokine/immunotherapy引用本文复制引用
基金项目
甘肃省卫生行业科研项目(GSWSKY-2019-63)
西北民族大学重大需求培育项目(319202301950)
出版年
2024
国家科技期刊平台
NSTL
万方数据