单细胞转录组测序在多发性骨髓瘤诊治和预后中的意义
Significance of single-cell transcriptome sequencing in diagnosis,treat-ment and prognosis of multiple myeloma
刘文慧 1吴涛2
作者信息
- 1. 甘肃中医药大学第一临床医学院,甘肃 兰州 730030;中国人民解放军联勤保障部队第九四〇医院血液科,甘肃 兰州 730050
- 2. 甘肃中医药大学第一临床医学院,甘肃 兰州 730030
- 折叠
摘要
多发性骨髓瘤(multiple myeloma,MM)是一种在临床和生物学都具有异质性的浆细胞恶性肿瘤.尽管进行了广泛的研究,在治疗方面取得了相当大的进展,但疾病的异质性和复发仍然是MM治疗的一大挑战.基于新一代测序的单细胞转录组测序(single-cell transcriptome sequencing,scRNA-seq)技术,能够从单细胞水平探测肿瘤细胞和骨髓微环境的异质性,从而提高我们对MM诊断分层、精确治疗和预后预测的认识.本文就scRNA-seq在MM诊断、治疗及预后中的应用进行综述.
Abstract
Multiple myeloma(MM)is a plasma cell malignancy that is heterogeneous in both clinical and bio-logical settings.Despite extensive research and considerable progress in treatment,disease heterogeneity and relapse re-main a major challenge in MM treatment.Single-cell transcriptome sequencing(scRNA-seq)technology based on next-generation sequencing can detect the heterogeneity of tumor cells and bone marrow microenvironment at the single-cell level,thereby improving our understanding of MM diagnosis stratification,precise treatment and prognosis prediction.This article reviews the application of scRNA-seq in the diagnosis,treatment and prognosis of MM.
关键词
单细胞转录组测序/多发性骨髓瘤/异质性/微环境Key words
single cell transcriptome sequencing/multiple myeloma/heterogeneity/microenvironment引用本文复制引用
基金项目
甘肃省创新基地和人才计划(甘肃省白血病临床医学研究中心)项目(21JR7RA015)
甘肃省重点研发计划(22YF7FA106)
联勤保障部队第九四〇医院血液病医学研究中心项目(2021yxky078)
出版年
2024
国家科技期刊平台
NSTL
万方数据