Diabetic neuropathy is a common chronic complication of diabetes and is characterized by high in-cidence and disability rates.It is the result of various metabolic imbalances,including disorders of glucose metabolism,lipid metabolism,and insulin signaling abnormalities caused by insulin deficiency or resistance.The pathogenesis of dia-betic neuropathy is closely related to lipid metabolism disorders.Disorders of lipid metabolism,especially abnormal changes in fatty acids,sphingolipids and cholesterol,are key causal factors and new therapeutic targets for diabetic neu-ropathy.This article reviews the disorder of lipid metabolism under diabetic conditions,and its role and mechanism in the occurrence and development of diabetic neuropathy,with the aim of providing new ideas for diabetic neuropathy treatment.
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