首页|铜代谢平衡和铜死亡在心血管疾病中的研究进展

铜代谢平衡和铜死亡在心血管疾病中的研究进展

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铜作为必需的微量元素,严重影响细胞代谢;干扰铜代谢平衡导致铜缺乏或过量均会引起相应疾病.铜代谢失衡或铜死亡通过介导细胞氧化应激、血管重塑以及干扰线粒体功能调控心血管疾病的发生发展,而铜螯合剂、铜离子载体、铜伴侣小分子抑制剂及膳食铜等可缓解铜代谢失衡或铜死亡介导的心血管疾病.本文综述了铜代谢平衡和铜死亡的分子机制及其在心血管疾病中的研究进展.
Progress in copper metabolic homeostasis and cuproptosis in cardiovas-cular diseases
As an essential trace element,copper has major effects on cell metabolism.Therefore,interfering with the balance of copper metabolism in such a way that leads to copper deficiency or excess causes disease.It has been reported that copper metabolic imbalance,or cuproptosis,affects the development of cardiovascular diseases by mediating cellular oxidative stress and vascular remodeling and by interfering with mitochondrial functions.Importantly,copper che-lators,copper ion carriers,small molecule inhibitors of copper chaperones,and dietary copper can alleviate cardiovascu-lar diseases caused by copper metabolic imbalance or cuproptosis.In this review,we comprehensively considered the mo-lecular mechanisms of copper metabolic homeostasis and cuproptosis,as well as their significance and therapeutic advances in cardiovascular diseases,aiming to provide insights on therapeutically targeting copper metabolic homeostasis and cupro-ptosis as a novel strategy for managing cardiovascular diseases.

copper metabolic homeostasiscuproptosiscardiovascular diseases

何平平、王艳、石蓓

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遵义医科大学附属医院心血管内科,贵州 遵义 563000

铜代谢平衡 铜死亡 心血管疾病

国家自然科学基金资助项目国家自然科学基金资助项目贵州省教育厅高校科技创新团队

8220031682160057黔教技[2023]074号

2024

中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCD北大核心
影响因子:1.065
ISSN:1000-4718
年,卷(期):2024.40(9)