Progress in mechanism of ferroptosis FSP1/CoQ10 signaling axis in Al-zheimer disease
赵炎 1贺小平 1张烨华 1董贤慧1
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作者信息
1. 河北中医药大学,河北省心脑血管病中医药防治研究重点实验室,河北 石家庄 050091
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摘要
铁死亡是一种以铁代谢失衡和脂质过氧化为特征的程序性细胞死亡方式.阿尔茨海默病(Al-zheimer disease,AD)是一种神经退行性疾病.研究表明,铁死亡的脂质过氧化过程与AD的病理过程密切联系,其中铁死亡抑制蛋白1(ferroptosis suppressor protein 1,FSP1)/辅酶Q10(coenzyme Q10,CoQ10)信号轴是铁死亡脂质过氧化过程中的关键调节因素.本文就FSP1/CoQ10信号轴在AD中的作用机制进行综述,以期为AD的治疗提供参考.
Abstract
Ferroptosis is a form of programmed cell death characterized by iron metabolic imbalance and lipid peroxidation.Alzheimer disease(AD)is a neurodegenerative condition.Studies have shown that lipid peroxidation through ferroptosis plays a significant role in the progression of AD.Ferroptosis suppressor protein 1(FSP1)/coenzyme Q10(CoQ10)signaling axis serves as a crucial regulatory element in the process of lipid peroxidation associated with ferropto-sis.This review explores the mechanisms of the FSP1/CoQ10 signaling axis in AD,aiming to present a novel therapeutic ap-proach for AD treatment.
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