首页|补充β-羟基丁酸在心血管疾病中应用和机制的研究进展

补充β-羟基丁酸在心血管疾病中应用和机制的研究进展

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心血管疾病的预防和治疗一直是相关领域关注的热点.本文探讨了在心肌缺血、心肌梗死、糖尿病心肌病、高血压、心肌炎症、肥厚型心肌病、心力衰竭等心血管疾病预防和治疗中,外源性和内源性补充β-羟基丁酸的应用及作用机制.外源性补充β-羟基丁酸可快速、直接地为心脏提供替代能量,从而预防和治疗心脏损伤,综合效果明显优于内源补充β-羟基丁酸.通过内源性的生酮饮食产生的脂肪酸,需要在体内氧化成β-羟基丁酸以提供能量,受基础疾病本身糖脂代谢的状态影响较大.目前,生酮饮食不推荐用于心肌缺血或心肌梗死的预防和治疗,以及糖尿病心肌病或高血压的治疗.
Progress in application and mechanism of β-hydroxybutyrate supplemen-tation in cardiovascular diseases
The prevention and treatment of cardiovascular diseases have always been a focus of attention in re-lated fields.This paper discusses the application and mechanism of exogenous and endogenous supplementation with β-hy-droxybutyrate in the prevention and treatment of cardiovascular diseases such as myocardial ischemia,myocardial infarc-tion,diabetic cardiomyopathy,hypertension,myocardial inflammation,hypertrophic cardiomyopathy and heart failure.Exogenous β-hydroxybutyrate supplementation can quickly and directly provide substitute energy for the heart and thus prevent and treat heart injury.The comprehensive effect of exogenous β-hydroxybutyrate supplementation is significantly better than that of endogenous β-hydroxybutyrate.Endogenous fatty acid,obtained through a ketogenic diet,needs to be oxidized to β-hydroxybutyrate in vivo for energy supply,which is greatly influenced by glucose and lipid metabolism under the conditions of the basic disease itself.At present,ketogenic diet is not recommended for use in the prevention and treat-ment of myocardial ischemia or myocardial infarction,and in the treatment of diabetic cardiomyopathy or hypertension.

β-hydroxybutyrateketogenic dietcardiovascular diseasesnutritional ketosis

李婷婷、张慧、张铭宸、王孝文、孙忠广

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山东第二医科大学康复医学院,山东 潍坊 261053

苏州大学附属第四医院康复医学科,江苏 苏州 215000

山东省公共卫生临床中心康复医学科,山东 济南 250132

β-羟基丁酸 生酮饮食 心血管疾病 营养酮症

国家食品安全风险评估中心科研联合攻关计划项目山东省自然科学基金青年项目2023年山东省大学生创新创业训练计划项目2023年潍坊医学院大学生创新创业训练计划项目

LH2022GG11ZR2022QH094S202310438041SX2023041

2024

中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCD北大核心
影响因子:1.065
ISSN:1000-4718
年,卷(期):2024.40(9)