首页|溶质载体家族3成员2表达与双硫死亡、铁死亡及肿瘤关系的研究进展

溶质载体家族3成员2表达与双硫死亡、铁死亡及肿瘤关系的研究进展

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铁死亡和双硫死亡与多种疾病相关.铁死亡的特征是铁离子和脂质活性氧的异常累积,而双硫死亡则是二硫化物的异常累积.溶质载体家族3成员2(SLC3A2)作为溶质载体家族的一员,不仅参与调控肿瘤细胞的增殖、迁移、侵袭和凋亡,还参与细胞铁死亡和双硫死亡,在肿瘤的发生发展中起关键作用.本文阐述了SLC3A2与双硫死亡、铁死亡和肿瘤关系的研究进展,旨在为癌症靶向治疗提供理论基础.
Progress in relationship between expression of solute carrier family 3 member 2,and disulfidptosis,ferroptosis and tumors
Ferroptosis and disulfidpthosis are associated with various diseases.Ferroptosis is distinguished by abnormal accumulation of iron ions and lipid reactive oxygen species,while disulfidptosis is marked by abnormal accumu-lation of disulfides.Solute carrier family 3 member 2(SLC3A2),a component of the solute carrier family,is implicated not only involved in the regulation of tumor cell proliferation,migration,invasion and apoptosis,but also in the processes of ferroptosis and disulfidptosis,playing a pivotal role in tumor growth and progression.This article provides an overview of the latest advancements in understanding the relationship between SLC3A2 and ferroptosis,disulfidptosis and tumors,aiming to establish a theoretical basis for targeted cancer therapies.

solute carrier family 3 member 2disulfidptosisferroptosistumor

马欢、代九菊、杨艳丽、周祖邦

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甘肃中医药大学第一临床医学院,甘肃 兰州 730000

甘肃省人民医院超声医学科,甘肃 兰州 730000

溶质载体家族3成员2 双硫死亡 铁死亡 肿瘤

甘肃省科技厅重点研发项目甘肃省兰州市人才创新创业项目甘肃省人民医院国家级科研项目培育计划

22YF7FA0982019-RC-11919SYPYB-26

2024

中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCD北大核心
影响因子:1.065
ISSN:1000-4718
年,卷(期):2024.40(9)