首页|3-吲哚丙酸在代谢性疾病中的研究进展

3-吲哚丙酸在代谢性疾病中的研究进展

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3-吲哚丙酸(3-IPA)是色氨酸经肠道微生物代谢的一种吲哚衍生物,在维持宿主健康和代谢平衡中起重要作用.3-IPA通过增强肠道上皮屏障、抗氧化、抗炎和调节免疫等作用,影响宿主生命活动.研究表明,体内3-IPA缺乏或肠道微生物失调,与肥胖、糖尿病和心血管疾病等多种代谢性疾病的发生发展有关,3-IPA可望成为诊断这些疾病的生物标志物.直接补充3-IPA或进行粪便微生物移植(FMT)等方法提高体内3-IPA水平,能有效改善代谢性疾病.该综述总结了3-IPA在代谢性疾病中的作用及其机制,通过改变饮食模式、改善微生物组成等措施提高体内3-IPA水平,以期为预防和治疗这些疾病提供参考.
Research progress of indole 3-propionic acid in metabolic diseases
Indole-3-propionic acid(3-IPA)is a metabolic product of tryptophan by gut microbiota,which plays an important role in maintaining host health and metabolic balance.3-IPA is suggested to influence host physical ac-tivities via enhancing the intestinal epithelial barrier,exerting anti-oxidative and anti-inflammatory effects,as well as im-mune modulation.Recent studies have indicated that deficiency of 3-IPA or gut microbiota imbalance is involved in the de-velopment of various metabolic disorders including obesity,diabetes and cardiovascular diseases,indicating 3-IPA is a po-tential marker in diagnosing these disorders.Furthermore,supplementation with 3-IPA or fecal microbiota transplantation(FMT)have been shown to effectively improve the metabolic diseases.This review summarizes the role and mechanism of 3-IPA in metabolic diseases,suggesting that strategies such as modifying dietary patterns or improving the microbial envi-ronment could provide new approaches for the prevention and treatment of these diseases.

indole-3-propionic acidmetabolic diseasestryptophanintestinal barrier

张浩原、赵真旺、张敏

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南华大学衡阳医学院心血管疾病研究所,生物信息与医学大数据教研室,湖南 衡阳 421001

湖北文理学院医学部基础医学院,湖北 襄阳 441053

3-吲哚丙酸 代谢性疾病 色氨酸 肠道屏障

国家自然科学基金资助项目湖北省自然科学基金青年资助项目湖南省教育厅科学研究项目

823005222023AFB04319B490

2024

中国病理生理杂志
中国病理生理学会

中国病理生理杂志

CSTPCD北大核心
影响因子:1.065
ISSN:1000-4718
年,卷(期):2024.40(10)