Advances in role of CRAC channels in pathogenesis of pancreatitis
Calcium release-activated calcium(CRAC)channels are non-selective calcium channels that are widely expressed in non-excitable cells.The opening of CRAC channels serves as a primary mechanism for calcium entry in various pancreatic and immune cells.Consequently,CRAC channels are crucial for maintaining Ca2+homeostasis and supporting numerous physiological functions of the exocrine pancreas.Numerous studies have identified CRAC channels as playing a pivotal role in many pathophysiological events that ultimately contribute to both acute and chronic pancreati-tis.In this review,we aim to highlight recent discoveries regarding the involvement of CRAC channels in the pathogenesis of acute and chronic pancreatitis,while also discussing current applications and future directions for CRAC channel-based drug development.
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