CRAC通道在胰腺炎发病机制中作用的研究进展
Advances in role of CRAC channels in pathogenesis of pancreatitis
彭爽 1孙泽林 2廖蝶 3杨晓淋 3柯路4
作者信息
- 1. 广州体育学院运动与健康学院,广东 广州 510500;广州体育学院国家体育总局运动技战术诊断与机能评定重点实验室,广东 广州 510500;暨南大学基础医学与公共卫生学院病理生理学系,国家中医药管理局病理生理实验室,广东 广州 510632
- 2. School of Biosciences,Cardiff University,Cardiff CF10 3AX,United Kingdom
- 3. 广州体育学院国家体育总局运动技战术诊断与机能评定重点实验室,广东 广州 510500
- 4. 南京大学医学院附属金陵医院(东部战区总医院)重症医学科,江苏 南京 210002
- 折叠
摘要
钙释放激活钙(CRAC)通道是一种在非兴奋性细胞中广泛表达的非选择性钙离子通道.CRAC通道的开放是不同胰腺细胞和免疫细胞中钙内流的主要机制.因此,CRAC通道对于胰腺外分泌的钙稳态及其多种生理功能至关重要.大量研究表明,CRAC通道在急性和慢性胰腺炎的病理生理过程中发挥着关键作用.本文旨在回顾CRAC通道在急性和慢性胰腺炎发病机制中的最新发现,并讨论基于CRAC通道药物开发的当前应用和未来方向.
Abstract
Calcium release-activated calcium(CRAC)channels are non-selective calcium channels that are widely expressed in non-excitable cells.The opening of CRAC channels serves as a primary mechanism for calcium entry in various pancreatic and immune cells.Consequently,CRAC channels are crucial for maintaining Ca2+homeostasis and supporting numerous physiological functions of the exocrine pancreas.Numerous studies have identified CRAC channels as playing a pivotal role in many pathophysiological events that ultimately contribute to both acute and chronic pancreati-tis.In this review,we aim to highlight recent discoveries regarding the involvement of CRAC channels in the pathogenesis of acute and chronic pancreatitis,while also discussing current applications and future directions for CRAC channel-based drug development.
关键词
钙释放激活钙通道/钙信号/钙超载/急性胰腺炎/慢性胰腺炎Key words
calcium release-activated calcium channels/calcium signaling/calcium overload/acute pancre-atitis/chronic pancreatitis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据