MGP翻译后修饰及其抑制血管钙化分子机制的研究进展
Progress in post-translational modification and molecular mechanism of MGP as a vascular calcification inhibitor
洪敏雯 1李清峰 2刘康 1梁丹 1李世新 1郝振宇1
作者信息
- 1. 扬州大学生物科学与技术学院,江苏 扬州 225009
- 2. 扬州大学附属医院,江苏 扬州 225009
- 折叠
摘要
基质γ-羧基谷氨酸蛋白(matrix gamma-carboxyglutamate protein,MGP)作为一种维生素K依赖性蛋白,是天然存在的血管钙化抑制蛋白.MGP的钙化抑制功能与其翻译后修饰紧密相关,特别是γ-谷氨酰羧化修饰和磷酸化修饰.但囿于其极低的溶解度和相对复杂的翻译后修饰,MGP抑制血管钙化的分子机制仍不清晰.在此,本文总结了目前有关MGP翻译后修饰与钙化抑制机制研究方面的进展和争论,阐述了由于MGP功能缺陷所引起的心脑血管疾病、慢性肾病和Keutel综合症等疾病的研究现状.希望本文能够促进我们对于MGP抑制血管钙化分子机制的理解,并有助于开发因MGP缺陷所导致的相关疾病治疗新方法.
Abstract
The matrix gamma-carboxyglutamate protein(MGP),a vitamin K-dependent protein,inhibits arte-rial calcification.The substance's ability to inhibit calcification is linked to its post-translational modifications,specifical-ly γ-glutamyl carboxylation and phosphorylation.The molecular mechanism of the calcification inhibitor remains unclear due to its low solubility and complicated post-translational modifications.In this section,we summarize current research and ongoing debates about post-translational modifications of MGP and its mechanism for inhibiting calcification.We re-viewed recent research on diseases associated with MGP deficiency,such as cardiovascular disease,chronic kidney dis-ease,and Keutel syndrome.Hopefully,this review can help us understand how MGP functions as a vascular calcification inhibitor and identify potential treatments for diseases resulting from its dysfunction.
关键词
基质γ-羧基谷氨酸蛋白/翻译后修饰/钙化抑制Key words
matrix gamma-carboxyglutamate protein/post-translational modification/calcification inhibition引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据