Progress in post-translational modification and molecular mechanism of MGP as a vascular calcification inhibitor
The matrix gamma-carboxyglutamate protein(MGP),a vitamin K-dependent protein,inhibits arte-rial calcification.The substance's ability to inhibit calcification is linked to its post-translational modifications,specifical-ly γ-glutamyl carboxylation and phosphorylation.The molecular mechanism of the calcification inhibitor remains unclear due to its low solubility and complicated post-translational modifications.In this section,we summarize current research and ongoing debates about post-translational modifications of MGP and its mechanism for inhibiting calcification.We re-viewed recent research on diseases associated with MGP deficiency,such as cardiovascular disease,chronic kidney dis-ease,and Keutel syndrome.Hopefully,this review can help us understand how MGP functions as a vascular calcification inhibitor and identify potential treatments for diseases resulting from its dysfunction.
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