Advances in role of IL-18 in differentiation,development and activation of eosinophils
Activated eosinophils are the core effector cells in immune responses.Interleukin-18(IL-18),a classical inflammasome-related cytokine,is reported to induce eosinophil differentiation,development and activation by binding with IL-18 receptor α,and thus promoting inflammation responses.Therefore,a thorough understanding of the role of IL-18 in eosinophil differentiation,development and activation is of great significance for the diagnosis and treat-ment of eosinophil-induced inflammatory diseases,and for the research and development of IL-18-related biological agents.
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