摘要
活化的嗜酸性粒细胞是机体炎症反应中的核心效应细胞.白细胞介素18(interleukin-18,IL-18)是一种经典的炎症小体相关的细胞因子,可通过与IL-18受体α结合诱导嗜酸性粒细胞分化、发育和活化进而促进机体的炎症反应.因此,系统认识IL-18在嗜酸性粒细胞分化、发育和活化中的作用对于嗜酸性粒细胞相关炎性疾病的诊疗和IL-18相关生物制剂的研发具有重要意义.
Abstract
Activated eosinophils are the core effector cells in immune responses.Interleukin-18(IL-18),a classical inflammasome-related cytokine,is reported to induce eosinophil differentiation,development and activation by binding with IL-18 receptor α,and thus promoting inflammation responses.Therefore,a thorough understanding of the role of IL-18 in eosinophil differentiation,development and activation is of great significance for the diagnosis and treat-ment of eosinophil-induced inflammatory diseases,and for the research and development of IL-18-related biological agents.
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