DNA聚合酶δ相互作用蛋白2在疾病中的作用
Role of DNA polymerase δ-interacting protein 2 in diseases
王科科 1肖冰 1鲁静朝1
作者信息
- 1. 河北医科大学第二医院心血管内科,河北 石家庄 050000
- 折叠
摘要
DNA聚合酶δ相互作用蛋白2(Poldip2)是由人Poldip2基因编码的一种多功能蛋白,最初因与人DNA聚合酶δ的p50亚基和增殖细胞核抗原结合而被发现.Poldip2与NADPH氧化酶4型亚基结合促进活性氧的产生,并在细胞骨架重塑中具有重要作用.此外,Poldip2参与DNA复制、DNA损伤修复、线粒体功能、细胞外基质调节、细胞周期、细胞黏附和迁移等多种细胞活动.本文总结了Poldip2在心血管疾病、呼吸系统疾病、肾脏疾病、神经系统疾病、癌症和内分泌疾病等疾病中的作用,为探索Poldip2作为疾病治疗靶点提供参考.
Abstract
DNA polymerase δ-interacting protein 2(Poldip2)is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase δ and proliferating cell nuclear antigen.It directly binds to NADPH oxidase 4 and plays an important role in reactive oxygen species production and cytoskeletal remodeling.It has been implicated in DNA replication,DNA damage repair,mitochondrial function,extracellular matrix regulation,cell cy-cle progression,focal adhesion turnover,and cell migration.This review summarizes the evidence and potential functions of Poldip2 in diverse diseases,including cardiovascular diseases,respiratory diseases,renal diseases,neurological dis-eases,cancers and endocrine diseases,to explore potential therapeutic targets for related diseases.
关键词
DNA聚合酶δ相互作用蛋白2/活性氧/线粒体Key words
DNA polymerase δ-interacting protein 2/reactive oxygen species/mitochondria引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据