Role of DNA polymerase δ-interacting protein 2 in diseases
DNA polymerase δ-interacting protein 2(Poldip2)is a multifunctional protein originally described as a binding partner of the p50 subunit of DNA polymerase δ and proliferating cell nuclear antigen.It directly binds to NADPH oxidase 4 and plays an important role in reactive oxygen species production and cytoskeletal remodeling.It has been implicated in DNA replication,DNA damage repair,mitochondrial function,extracellular matrix regulation,cell cy-cle progression,focal adhesion turnover,and cell migration.This review summarizes the evidence and potential functions of Poldip2 in diverse diseases,including cardiovascular diseases,respiratory diseases,renal diseases,neurological dis-eases,cancers and endocrine diseases,to explore potential therapeutic targets for related diseases.
DNA polymerase δ-interacting protein 2reactive oxygen speciesmitochondria
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