摘要
亮氨酸氨基肽酶3(leucine aminopeptidase 3,LAP3)是一种可以通过催化蛋白质或肽底物氨基端亮氨酸残基水解而完成蛋白质转化和新陈代谢的酶,对细胞的生长发育至关重要.LAP3的异常表达往往会导致疾病的发生,目前已发现LAP3在包括乳腺癌、肝细胞癌、卵巢癌和胶质瘤在内的多种癌症中表达升高.进一步研究表明,LAP3可以通过调控癌细胞间信号传导、上皮-间充质转化、细胞自噬、细胞周期和细胞精氨酸合成与代谢来影响肿瘤细胞的增殖、迁移和侵袭能力,进而促进恶性肿瘤的发生.当前,针对LAP3的靶向治疗药物也正成为新的研究方向.本综述总结了LAP3的最新进展,分析LAP3在恶性肿瘤诊断和预后中的临床价值及其致癌作用和潜在的分子机制,以期为恶性肿瘤诊断和治疗提供新的启示.
Abstract
Leucine aminopeptidase 3(LAP3)is an enzyme crucial for protein transformation and metabo-lism,as it catalyzes the hydrolysis of amino terminal leucine residues on protein or peptide substrates.This enzymatic ac-tivity is essential for cell growth and development.Abnormal expression of LAP3 is often linked to various diseases.Re-cent studies have indicated that LAP3 expression is elevated in several types of cancer,including breast cancer,hepatocel-lular carcinoma,ovarian cancer,and glioma.Further research has demonstrated that LAP3 influences the proliferation,migration,and invasion of tumor cells by mediating signaling pathways among cancer cells,epithelial-mesenchymal transi-tion,autophagy,cell cycle,and arginine synthesis and metabolism,thereby promoting the development of malignant tu-mors.Consequently,targeted therapies aimed at LAP3 are emerging as a promising area of research.This review summa-rizes the latest advances related to LAP3,evaluates its clinical significance in the diagnosis and prognosis of malignant tu-mors,and explores its carcinogenic effects and potential molecular mechanisms,aiming to offer new insights for the diag-nosis and treatment of these tumors.
国家科技期刊平台
NSTL
万方数据