Progress in role of leucine aminopeptidase 3 in occurrence,diagnosis and treatment of cancer
Leucine aminopeptidase 3(LAP3)is an enzyme crucial for protein transformation and metabo-lism,as it catalyzes the hydrolysis of amino terminal leucine residues on protein or peptide substrates.This enzymatic ac-tivity is essential for cell growth and development.Abnormal expression of LAP3 is often linked to various diseases.Re-cent studies have indicated that LAP3 expression is elevated in several types of cancer,including breast cancer,hepatocel-lular carcinoma,ovarian cancer,and glioma.Further research has demonstrated that LAP3 influences the proliferation,migration,and invasion of tumor cells by mediating signaling pathways among cancer cells,epithelial-mesenchymal transi-tion,autophagy,cell cycle,and arginine synthesis and metabolism,thereby promoting the development of malignant tu-mors.Consequently,targeted therapies aimed at LAP3 are emerging as a promising area of research.This review summa-rizes the latest advances related to LAP3,evaluates its clinical significance in the diagnosis and prognosis of malignant tu-mors,and explores its carcinogenic effects and potential molecular mechanisms,aiming to offer new insights for the diag-nosis and treatment of these tumors.
国家科技期刊平台
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