Meta-analysis of the efficacy and safety of Xingnaojing Injection compared with usual care alone in the treatment of acute ischemic stroke
Objective To systematically evaluate the efficacy and safety of Xingnaojing Injection as an adjuvant therapy for acute ischemic stroke by using meta-analysis.Methods PubMed,CNKI,VIP,Wanfang and SinoMed databases were systematically searched,and the retrieved literature was screened according to the inclusion criteria established in advance.Two authors independently extracted and checked the data of the final included literature.The outcome data were combined and analyzed using RevMan 5.4 software.Results Ten randomized controlled trials involving 956 patients with acute ischemic stroke were eventually included.The outcome evaluation suggested that the addition of Xingnaojing Injection to conventional therapy was better than conventional therapy alone in improving neurological deficits[including lower deficit scores(MD=-5.80,95%CI:-7.30～-4.30,P＜0.000 1)and higher rates of neurological improvement(RR = 1.15,95%CI:1.08～1.23,P＜0.000 1)],improving viability(MD = 9.13,95%CI:7.02～11.24,P＜0.000 01),lowering NIHSS scores in stroke(MD =-3.25,95%CI:-5.21～-1.28,P=0.001),and reducing coma(MD=2.63,95%CI:1.12～4.14,P=0.000 6);there was no statistical difference in the incidence of adverse events between groups(RR=0.73,95%CI:0.26～2.09,P=0.56).Conclusion The efficacy of the addition of Xingnaojing Injection in patients with acute ischemic stroke is enhanced and safer in terms of improving neurological deficits,improving functional capacity,reducing NIHSS scores and reducing coma.
NETL
NSTL
万方数据
维普
