Systematic review and Meta-analysis of efficacy and safety of Xuanfei Zhisou Mixture in treatment of bronchitis in children
Objective This study systematically evaluated the effectiveness and safety of Xuanfei Zhisou Mixture in the treatment of bronchitis in children.Methods The databases including CNKI,Wanfang,VIP,SinoMed,PubMed,EMbase and Cochrane Library were systematically searched for randomized controlled trial(RCT)of Xuanfei Zhisou Mixture in the treatment of bronchitis in children reported from database inception to June 2022.The methodological quality of the included RCTs was evaluated via the Cochrane risk of bias tool ROB2.0 and meta-analysis was performed using RevMan 5.4 statistical software.Results A total of 7 RCTs with 771 children aged 0～14 years were included.The overall methodological quality of the included studies was not high.The meta-analysis results showed that Xuanfei Zhisou Mixture combined with conventional therapy(anti-infective and symptomatic therapy)can improve the total effective ratio(clinical effectiveness)and shorten the duration time of cough and pulmonary rales in children with bronchitis.Xuanfei Zhisou Mixture combined with recombinant human interferon can not only improve the total effective rate,but also shorten the duration time of cough,wheezing and pulmonary rales.Conclusion The Xuanfei Zhisou Mixture can shorten the duration of fever,cough and pulmonary rales more than ambroterol oral liquid.There were no significant adverse events in 4 studies and other studies were not reported.In conclusion,Xuanfei Zhisou Mixture has potential advantages in improving the symptoms of fever,cough,pulmonary rales in children with bronchitis compared with conventional western medicine therapy.However,in view of the limited number of included studies,small sample size and low methodological quality,the results of this study need to be confirmed with high-level clinical trials.
Xuanfei Zhisou MixtureBronchitis in childrenSystematic reviewMeta-analysis
NETL
NSTL
万方数据
维普
