Study on compatibility rationality of Wuhuang Guwai Powder for the treatment of rheumatoid arthritis based on network pharmacology
Objective To explore the compatibility rationality of Wuhuang Guwai Powder for the treatment of rheumatoid arthritis.Methods Network pharmacology was used to predict and screen the targets,function and pathways related to rheumatoid arthritis in Wuhuang Guwai Powder including dispelling wind dampness group(DWDG),relieving exterior syndrome group(RESG),heat-clearing and detoxicating group(HCDG).The characteristics and compatibility rules of this prescription in treating RA were analyzed combined with data.Results A total of 90 active components and 360 targets were obtained,and 237 KEGG pathways were enriched in herb groups of Wuhuang Guwai Powder;It mainly involves inflammatory reaction,virus infection,endocrine regulation,pain control,blood lipid regulation and other related processes.Conclusion On the basis of the synergistic treatment of rheumatoid arthritis,herb groups of Wuhuang Guwai Powder has its own function characteristics.DWDG were mainly related to anti inflammation,pain relief and endocrine regulation.RESG and HCDG was mainly involved in infection regulation,inflammatory immune response and lipid regulation.The results showed that DWDG as the king drugs,played a synergistic therapeutic role with the help of the RESG and HCDG,and the compatibility of Wuhuang Guwai Powder was reasonable.
NETL
NSTL
万方数据
维普
