Exploring the mechanism of the effect of Xiaoqinglong Decoction Modified Prescription on airway inflammatory response in COPD rats
Objective To study interleukin-6,tumor necrosis factor-ɑ and Interferon-γin rat model of chronic obstructive pulmonary disease(COPD),in order to explore the mechanism of Xiaoqinglong Decoction Modified Prescription in the treatment of COPD airway inflammation,the content changes in rat serum and alveolar lavage fluid were observed.Methods Sixty adult male SD rats were divided into the control group(20 rats),the model group(20 rats)and the intervention group(20 rats).The animal model of COPD rats was established by repeated cigarette smoking and intratracheal injection of lipopolysaccharide.The intervention group was fed with Xiaoqinglong Decoction Modified Prescription.Detection of IL-6,TNF-ɑ and IFN-γ in rat serum and alveolar lavage fluid by enzyme-linked immunosorbent assay content was measured by ELISA.Results In the model group,TNF-α in serum and alveolar lavage fluid and IL-6 significantly higher than the intervention group,IFN-γexpression decreased.Conclusion In the COPD rat model,the Xiaoqinglong Decoction Modified Prescription may affect the level of airway inflammatory factors,thus improve airway inflammation to a certain extent.
NETL
NSTL
万方数据
维普
