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三联疗法预防二次剖宫产产后出血的效果观察

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目的 探究三联疗法预防二次剖宫产产后出血的效果观察.方法 选取 2020 年 6 月~2023 年 6 月纳入的 80 例二次剖宫产产妇,按照随机数字法分为对照组(n= 40)和观察组(n= 40),其中对照组采用缩宫素和氨甲环酸治疗,观察组采用缩宫素、氨甲环酸联合卡前列素氨丁三醇注射液治疗.观察和比较两组产妇不同时间的出血量和凝血功能,记录不良反应发生情况.结果 两组患者术中出血量差异无统计学意义(P>0.05),但观察组术后 2 h、术后 24 h出血量少于对照组(P<0.05);两组产妇产前的PT、TT、APTT、FIB、Hb指标差异无统计学意义(P>0.05);但观察组产后 24 h的PT、TT、APTT指标均低于对照组,观察组产后 24 h的FIB、Hb均高于对照组(P<0.05);观察组不良反应发生率为 15.00%,对照组不良反应发生率为 7.50%,两组差异无统计学意义(P>0.05).结论 二次剖宫产产后出血的产妇采用缩宫素、氨甲环酸联合卡前列素氨丁三醇注射液预防效果显著,有效改善产妇的凝血功能,减少产妇的出血量.
Observation on the effect of triple therapy on preventing hemorrhage after second caesarean section
Objective To observe the effect of triple therapy on preventing hemorrhage after second caesarean section.Methods A total of 80 women with secondary cesarean section in our hospital from June 2020 to June 2023 were selected and divided into the control group(n= 40)and the observation group(n= 40)according to random number method.The control group was treated with oxytocin and tranexamic acid,while the observation group was treated with oxytocin,tranexamic acid combined with carprost triol injection.The blood loss and coagulation function of the two groups at different time were observed and compared,and the occurrence of adverse reactions was recorded.Results There was no difference in the amount of intraoperative blood loss between the two groups(P>0.05),but the amount of blood loss in the observation group was less than that in the control group at 2 h and 24 h after surgery(P<0.05).There were no differences in PT,TT,APTT,FIB and Hb indexes between the two groups(P>0.05).However,PT,TT and APTT indexes in the observation group were lower than those in the control group 24 hours after delivery,and FIB and Hb in the observation group 24 hours after delivery were higher than those in the control group(P<0.05).The incidence of adverse reactions was 15.00%in the observation group and 7.50%in the control group,with no statistical significance between the two groups(P>0.05).Conclusion The use of oxytocin,tranexamic acid combined with carprost trochantriol injection can effectively improve the coagulation function of the parturients and reduce the amount of bleeding after the second caesarean section.

Carprost triol injectionOxytocinTranexamic acidCaesarean sectionPostpartum hemorrhage

黄丽芝、张红燕、符娜娜、张盈

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珠海市香洲区人民医院妇产科,广东珠海 519000

珠海市香洲区第二人民医院妇产科,广东珠海 519000

珠海市香洲区人民医院药剂部,广东珠海 519000

卡前列素氨丁三醇注射液 缩宫素 氨甲环酸 剖宫产 产后出血

2023

中国处方药
南方医药经济研究所

中国处方药

影响因子:0.649
ISSN:1671-945X
年,卷(期):2023.21(12)
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