Curative effect of edaravone dextrocamphorol combined with aspirin in the treatment of ischemic stroke
Objective To investigate the efficacy of edaravone dextrocamphorol combined with aspirin in the treatment of ischemic stroke.Methods 186 patients with ischemic stroke from June 2021 to March 2023 were selected as research objects and divided into two groups by random number table method.Both groups received conventional treatment,the control group(93 cases)was given aspirin enteric-coated tablets,the observation group(93 cases)was given edaravone dexcamphorol combined with aspirin.The therapeutic effect,neurological function(NIHSS)score before and after treatment,daily viability(ADL)score,hemorheology level,serum oxidative stress level[superoxide dismutase(SOD),malondialdehyde(MDA)]and and nerve damage markers[Neuron-specific enolase(NSE),specific protein 100-β(S-100β)]were compared between the two groups.Results The effective rate of the observation group was 87.10%(81/93)higher than that of the control group 70.97%(66/93),and a statistically significant differen ce was observed(P＜0.05);After treatment,NIFSS score was decreased and ADL score was increased in both groups.Compared with control group,NIFSS score in the observation group was lower and ADL score was higher,and a statistically significant difference was observed(P＜0.05);After treatment,the levels of whole blood high tangential viscosity,whole blood low tangential viscosity and plasma viscosity in both groups were decreased,and the levels in the observation group were lower,a statistically significant difference was observed(P＜0.05);After treatment,the level of MDA in both groups decreased,and the observation group was lower,and the level of SOD in both groups increased,and the observation group was higher,a statistically significant difference was observed(P＜0.05);After treatment,the levels of NSE and S-100β were decreased in both groups,and the levels in the observation group were lower,a statistically significant difference was observed(P＜0.05).Conclusion Edaravone dexcamphorol combined with aspirin can improve the neurological function of patients with ischemic stroke,reduce brain cell damage,reduce oxidative stress,improve the ability of daily living,and regulate hemorheology to enhance the therapeutic effect.
Edaravone dextrocamphenolAspirinIschemic strokeNerve functionAbility of daily livingHemorheology
NETL
NSTL
万方数据
维普
