Mechanism of "treating different diseases with the same method" of Sini Powder in the treatment of depression,functional dyspepsia and breast hyperplasia based on network pharmacology
Objective The network pharmacology method was used to study the material basis and action mechanism of"treating different diseases with same method"of Sini Powder for depression,functional dyspepsia and breast hyperplasia.Methods The Sini Powder possible active components were obtained through the TCMSP database and potential targets of the active components were predicted using the Swiss Target Prediction database.The relevant targets of depression,functional dyspepsia and breast hyperplasia were searched in Genecard,Disgenet and OMIM databases.The protein interactions were understood through the STRING website and visualized using Cytoscape 3.8.0 software.Gene Ontology(GO)analysis and Kyoto Genomics and Genomics Encyclopedia(KEGG)analysis were performed using the DAVID database.Results It was predicted to obtain 125 active components and 246 common targets of"treating different diseases with same method"of Sini Powder,569 GO functions and 157 signaling pathways were obtained by enrichment analysis(P＜0.01,FDR＜0.01).The mechanism of action may be related to cancer,PI3K-Akt,endocrine resistance,and other signaling HIF-1 pathways.Conclusion The effect and characteristics of Sini Powder in depression,functional dyspepsia and breast hyperplasia treatment were in multi-ingredient,multi-target and multi-pathway,which would provide new research ideas and methods for the interpretation of the scientific connotation of Sini Powder on"treating different diseases with the same method".
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