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基于数据挖掘分析中药治疗功能性消化不良肝胃不和证的用药规律

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目的 基于数据挖掘,探讨并总结近十年中医药治疗功能性消化不良肝胃不和证的用药规律。方法 从中国知网中检索出相关的 139 篇文献,用从中提取出的 139 条方剂建立处方数据库,并进行频数分析、关联规则及聚类分析。结果 139 条方剂中,高频方剂为柴胡疏肝散、舒胃汤、柴枳平肝汤。药物的四气以温、平为主,五味以辛、苦、甘为主,归经以脾、胃、肺、肝为主。得到 4 个聚类方,分别为:枳壳、川芎、砂仁、佛手、甘草、柴胡、白芍;枳实、延胡索、香附、神曲等。得到置信度较高的药对有"郁金-柴胡、延胡索-柴胡、川芎-白芍、白芍-柴胡、甘草-柴胡"。结论 治疗肝胃不和型功能性消化不良,应注意疏肝理气解郁与调和脾胃升降并重,在用药上一方面重视能抗抑郁和促进胃肠动力的中药,另一方面使用温平之药以免伤及脾胃正气,同时不可只着眼于肝、胃、脾,还应顾护肺的功能,注重调和阴阳。
Data mining of the treatment regularity of traditional Chinese medicine for functional dyspepsia with liver and stomach disharmony
Objective Based on data mining,this study discusses and summarizes the medication rules of traditional Chinese medicine in the treatment of functional dyspepsia with disharmony between liver and stomach in the past decade.Methods 139 related papers were retrieved from CNKI,and the prescription database was established with the 139 prescriptions extracted from it,and the frequency statistics,association rules and cluster analysis were performed.Results Among the 139 prescriptions,the high-frequency prescriptions were Chaihu Shugan Powder,Shuwei Decoction and Chaizhi Pinggan Decoction.The four properties of herbs were mainly warm and normal pulse,five kinds of flavour were mainly pungent,bitter and sweet,and the meridian distribution were mainly spleen meridian,stomach meridian,lung meridian and liver meridian.Four clusters were obtained,namely:Fructus Aurantii,Ligusticum chuanxiong,Fructus Amomi,Bergamot,Licorice,Chaihu,and White Peony;Fructus Aurantii,Corydalis yanhusuo,Xiangfu,Shenqu,etc.The drug pairs with high confidence were"aromatic turmeric-Chinese thorowax,Corydalis ambigua-Chinese thorowax,Chuanxiong-herbaceous peony,herbaceous peony-Chinese thorowax,Licorice-Chinese thorowax".Conclusion For treating functional dyspepsia caused by disharmony between liver and stomach,it is important to regulate liver qi and relieve depression as well as harmonize spleen and stomach functions.In terms of medication,on one hand,attention should be paid to Chinese herbs that can counteract depression and enhance gastrointestinal motility;on the other hand,mild and balanced herbs should be used to avoid injuring spleen and stomach qi.Moreover,it is not advisable to focus only on liver,stomach and spleen;lung function should also be taken care of,and yin-yang balance should be emphasized.

Functional dyspepsiaLiver and stomach disharmonyData mining

冯璐璐、余珊珊

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湖北中医药大学,武汉 430000

湖北中医药大学附属黄石中医医院,湖北黄石 435000

功能性消化不良 肝胃不和证 数据挖掘

朱致纯全国名老中医药专家传承工作室建设项目

国中医药人教发[2019]41号

2024

中国处方药
南方医药经济研究所

中国处方药

影响因子:0.649
ISSN:1671-945X
年,卷(期):2024.22(1)
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