Rapid health technology assessment of SMOF injection in adult hospitalized patients
Objective Clinical trials reported that multiple oil-fat emulsions(SMOF)had a positive effect on immune function,but the results were inconsistent compared with other lipid emulsions.The method of rapid health technology assessment was used to provide evidence-based medical evidence for clinical medication decisions.Methods Computer searches were conducted on the Cochrane Library,PubMed,Embase,China National Knowledge Infrastructure,and Wanfang Database to collect systematic reviews/Meta-analyses and pharmacoeconomic studies of SMOF used in adult inpatients.Results A total of 7 studies were included,including 5 Meta-analyses and 2 pharmacoeconomic studies.In terms of effectiveness:the results of the 5 included Meta-analyses are basically consistent.Generally,SMOF has varying degrees of positive effect on alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transferase(GGT),total bilirubin(TB),triglyceride(TG),etc.liver function markers serum concentrations,which can shorten hospitalization time(LOS)and improve clinical outcomes.No significant effect of SMOF was observed in improving inflammatory markers C-reactive protein(CRP)and interleukin-6(IL-6).Safety:The included studies have shown that the incidence of adverse events(AE)of SMOF is comparable to that of other fat emulsions.Economy:Two pharmacoeconomic studies all suggest that SMOF has significant economic advantages.Conclusion SMOF has significant advantages in effectiveness,safety and economy when used in adult inpatients,and has high clinical value.
SMOFRapid health technology assessmentEffectivenessSafetyEconomy
万方数据
维普
