Objective Clinical trials reported that multiple oil-fat emulsions(SMOF)had a positive effect on immune function,but the results were inconsistent compared with other lipid emulsions.The method of rapid health technology assessment was used to provide evidence-based medical evidence for clinical medication decisions.Methods Computer searches were conducted on the Cochrane Library,PubMed,Embase,China National Knowledge Infrastructure,and Wanfang Database to collect systematic reviews/Meta-analyses and pharmacoeconomic studies of SMOF used in adult inpatients.Results A total of 7 studies were included,including 5 Meta-analyses and 2 pharmacoeconomic studies.In terms of effectiveness:the results of the 5 included Meta-analyses are basically consistent.Generally,SMOF has varying degrees of positive effect on alanine aminotransferase(ALT),aspartate aminotransferase(AST),and gamma-glutamyl transferase(GGT),total bilirubin(TB),triglyceride(TG),etc.liver function markers serum concentrations,which can shorten hospitalization time(LOS)and improve clinical outcomes.No significant effect of SMOF was observed in improving inflammatory markers C-reactive protein(CRP)and interleukin-6(IL-6).Safety:The included studies have shown that the incidence of adverse events(AE)of SMOF is comparable to that of other fat emulsions.Economy:Two pharmacoeconomic studies all suggest that SMOF has significant economic advantages.Conclusion SMOF has significant advantages in effectiveness,safety and economy when used in adult inpatients,and has high clinical value.
关键词
多种油脂肪乳/快速卫生技术评估/有效性/安全性/经济性
Key words
SMOF/Rapid health technology assessment/Effectiveness/Safety/Economy
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