Analysis of drug gene polymorphisms and precise drug use in 538 patients with hypertension
Objective To analyze the polymorphism of drug genes in patients with hypertension,and explore the clinical application value of gene detection of hypertension drugs,so as to provide evidence for accurate medication.Methods Using descriptive statistical analysis methods,the results of anti hypertensive drug related gene testing in 538 patients with hypertension from May 2019 to January 2023 in Chongqing Yongchuan Hospital of Traditional Chinese Medicine were statistically analyzed.Results In 538 patients with hypertension,the frequency of CYP3A5*3 gene mutations was the highest(67.66%),while the frequency of CYP2C9*3 gene mutations was the lowest(4.74%)in the drug metabolizing enzyme genes;The frequency of mutations in the ADRB1(c.1165 G＞C)gene is the highest at 72.96%,while the frequency of mutations in the AGTR1(c.1166 A＞C)gene is the lowest at 5.39% in the drug target genes;Most are relatively sensitive to β receptor blockers and calcium channel blockers(CCB),and their responses to angiotensin converting enzyme inhibitors(ACEI)and angiotensinⅡreceptor antagonists(ARB)are at normal levels.Conclusion Hypertensive patients may have different reactions to different antihypertensive drugs,and their CYP2C9*3 and ACE(I/D)gene polymorphisms may also differ from those of the normal population.Before selecting such drugs for antihypertensive treatment,drug genetic testing can be conducted to guide clinical precise medication.
万方数据
维普
