The clinical observation of Qingwei Powder combined with disposable root canal in the treatment of acute pulpitis and its effect on serum TNF-α,IL-8 and CD14 levels
The clinical observation of Qingwei Powder combined with disposable root canal in the treatment of acute pulpitis and its effect on serum TNF-α,IL-8 and CD14 levels
Objective To analyze the improvement of pain and inflammation in patients with acute pulpitis treated with modified Qingwei Powder combined with disposable root canal,and to observe its long-term effect.Methods 78 patients with acute pulpitis treated in a hospital from January 2020 to December 2022 were selected as the research object.According to the differences of treatment methods,the patients were divided into single group(n = 40,simple one-time root canal treatment)and combined group(n = 38,with addition and subtraction of Qingwei powder after operation).The improvement of pain scores,traditional Chinese medicine syndrome scores,serum C-reactive protein,interleukin-8,tumor necrosis factor-α,and leukocyte differentiation antigen-14 inflammatory factor indicators before and after treatment were compared between the two groups.All patients were followed up for half a year.The improvement of periodontal index,and cure rate were compared and analyzed between the two groups.Results Before treatment,there was no statistically significant difference in pain scores,IL-8,TNF-α,CRP,and CD14 levels between the two groups(P＞0.05).After 2 weeks of treatment,compared with before treatment,the pain scores and levels of IL-8,TNF-α,CRP,and CD14 in both groups decreased,and compared with the single group,the combined group had lower pain scores and levels of IL-8,TNF-α,CRP,and CD14(P＜0.05).The scores of traditional Chinese medicine symptoms such as toothache,tongue and pulse in the two groups were significantly lower than those before treatment(P＜0.05),and the scores of traditional Chinese medicine symptoms in the combined group were significantly lower than those in the single group(P＜0.05).Before treatment,there was no significant difference in PD,GI and PLI between the two groups(P＞0.05);After 6 months of treatment,compared with before treatment,PD,GI and PLI in the two groups decreased,After 6 months of treatment,compared with the single group,PD,GI and PLI in the combined group decreased(P＜0.05).Compared with the single group,the cure rate in the combined group was significantly higher(P＜0.05).Conclusion Compared with single one-time root canal therapy,the addition and subtraction of Qingwei Powder in the treatment of acute pulpitis can effectively alleviate pain,improve inflammatory response,promote postoperative periodontal recovery and improve long-term curative effect.
关键词
急性牙髓炎/根管治疗术/中医症候/清胃散/炎症反应/牙周指数
Key words
Acute pulpitis/Root canal therapy/TCM symptoms/Qingwei Powder/Inflammatory response/Periodontal index
维普
万方数据