Meta analysis of the clinical efficacy of Shentong Zhuyu Decoction in the treatment of diabetic peripheral neuropathy
Objective To evaluate the clinical efficacy of Shentong Zhuyu Decoction in the treatment of diabetic peripheral neuropathy(DPN).Methods By searching VIP,CNKI,CBM,PubMed,Web of science and other databases,we collected and collated the randomized controlled trials of Shentong Zhuyu Decoction in the treatment of diabetic peripheral neuropathy from 2000 to January 2023.RevMan 5.4 software was used to analyze dates.Results 10 publications with 761 patients were included.The Meta-analysis showed that the total clinical effective rate in the experimental group was better than that in the control group[OR = 3.60,95%CI(2.43,5.31),P＜0.00001],and the common peroneal motor nerve[MD=2.79,95%CI(2.01,3.57),P＜0.000 01]and common peroneal sensory nerve conduction velocity[MD =1.66,95%CI(0.88,2.45),P＜0.000 1],median motor nerve[MD = 3.34,95%CI(2.33,4.34),P＜0.000 01]and median sensory nerve conduction velocity[MD = 1.32,95%CI(0.38,2.26),P= 0.006]were faster than those in the control group.The visual analogue scales(VAS)scores[MD=-1.09,95%CI(-1.35,-0.83),P＜0.000 1]and total cholesterol level[MD =-1.06,95%CI(-1.73,-0.39),P= 0.002]in the experimental group were lower than those in the control group.Conclusion Shentong Zhuyu Decoction can improve the clinical efficacy in the treatment of diabetic peripheral neuropathy,increase the conduction velocity of common peroneal nerve and median nerve,reduce VAS score and total cholesterol level,and don't casue serious adverse events.
万方数据
维普
