Comparison of content determination methods for galantamine hydrobromide
Objective To comparative study on different content determination methods of galantamine hydrobromide,in order to provide a foundation for the improvement of quality standard.Methods The contents of galantamine hydrobromide were determined by non-aqueous titration,acid-base potentiometric titration and high performance liquid chromatography,with reference to the Chinese Pharmacopoeia 2020,British Pharmacopoeia 2023,European Pharmacopoeia 11.0,United States Pharmacopoeia 2023 and relevant literature.Results The average recovery of non-aqueous titration was 99.79%(RSD= 0.46%);the average recovery of acid-base potentiometric titration was 100.67%(RSD= 0.32%);the average recoveries of high-performance liquid chromatography were 99.78%(RSD = 0.82%)and 99.85%(RSD = 0.66%),respectively.Conclusion The content results of acid-base potentiometric titration were higher,while the results of non-aqueous titration and HPLC were more accurate,which are more suitable for the content determination of galantamine hydrobromide.
万方数据
维普
