Analysis on drug resistance of pathogens and the significance of anti-infection treatment in a grade-A tertiary hospital from 2019 to 2021
Objective To understand the distribution and drug resistance changes of pathogens from 2019 to 2021,and to provide evidence for clinically rational use of antibacterial drugs.Methods The clinical data were collected from various samples in a hospital wards.Antimicrobial susceptibility testing was performed by automated system or Kirby-Bauer method.And the distribution,composition and drug resistance of pathogens were analyzed statistically.Results 5 304 strains of pathogens were isolated in the three years,including 4 257(80.3%)strains of gram-negative bacteria and 1 047(19.7%)strains of gram-positive bacteria.The top five isolated pathogens were Escherichia coli(23.1%),Klebsiella spp.(19.4%,mainly Klebsiella pneumoniae),Pseudomonas spp.(12.4%,mainly Pseudomonas aeruginosa),Acinetobacter spp.(8.2%,mainly Acinetobacter baumannii)and Staphylococcus aureus(8.1%).The resistance rate of Enterobacteriaceae to carbapenems was 2.2%,among which the resistance rates of Escherichia coli and Klebsiella pneumoniae were 1.9%and 1.4%respectively;resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 21.7%and 18.1%respectively,while resistance rates of Acinetobacter baumannii to them were 58.4%and 57.2%respectively;resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannii(except 2019)to carbapenems showed an upward trend.Staphylococcus spp.accounted for the highest proportion of gram-positive bacteria.The isolation rates of methicillin-resistant Staphylococcus aureus(MRSA)from 2019 to 2021 were 30.4%,29.2%and 36.2%respectively(P＞0.05).The resistance rates of methicillin-sensitive Staphylococcus aureus(MSSA)to penicillin,oxacillin and clindamycin were lower than those of MRSA(P＜0.05);however the rates of MSSA to gentamicin and sulfamethoxazole/trimethoprim were higher than those of MRSA(P＜0.05).Staphylococcus aureus resistant to linezolid,vancomycin,tegecycline,quinupristin/dalfopristin was not isolated.Conclusion The clinical pathogens from 2019 to 2021 are mainly gram-negative bacteria,which have high resistance rates to commonly used antibacterial agents.Especially carbapenem resistant strains continue to emerge now,so it is of great significance to reasonably select antibacterial agents.
BacteriaDrug resistanceAntimicrobial agentsMulti-drug resistant bacteriaRational drug use
万方数据
维普
