Correlation analysis of T cell subsets and adverse effects in tumor patients with immune checkpoint inhibitors
Objective To observe the changes of T lymphocyte subsets in peripheral blood of different cancer patients before and after tumor cell immune checkpoint inhibitor treatment,and to explore the correlation with adverse reactions.Methods The clinical data of 60 tumor patients receiving ICIs in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from August 2021 to December 2022 were collected retrospectively,comparing the changes of CD3+,CD4+,CD8+and CD4+/CD 8+before and after ICI,and the influencing factors of T cell subsets were analyzed.Results CD3+,CD4+counts and CD4+/CD8+after ICI were higher than those before treatment.The differences were statistically significant(P＜0.05);although CD8+decreased,the difference was not statistically significant(P＞0.05).Among them,CD4+/CD8+with long time tended to approach the normal range of 0.7～2.78,and the lower the probability of adverse reactions,the lower the grade of irAEs.Conclusion The T lymphocyte results of ctopathological immunoassay may be used as one of the indicators of clinical guidance to prevent immune-related adverse reactions,and the combined application of traditional Chinese medicine during treatment can significantly reduce the clinical adverse reactions.
ImmunotherapyAdverse reactionsT cell subsetTraditional Chinese medicine
万方数据
维普
