Rapid health technical evaluation on the efficacy and safety of ursodeoxycholic acid in the treatment of primary biliary cholangitis
Objective Rapid health technical evaluation on the efficacy and safety of ursodeoxycholic acid in the treatment of primary biliary cholangitis(PBC),provide evidence-based basis for clinical treatment.Methods Search multiple databases;Key words used:ursodeoxycholic acid,UDCA,system review,system evaluation,Meta-analysis,cost-effectiveness economic evaluation;The search scope is specified from the establishment of the database to December 31,2021;Main outcome measures:mortality,liver transplantation rate,death or liver metastasis,liver disease related mortality,incidence of liver decompensation,improvement of fatigue symptoms,improvement of itching symptoms,serum total bilirubin(STB),aspartate aminotransferase(AST),alanine aminotransferase(ALT),γ-glutamic transferase(GGT),prothrombin time(PT),IgM,alkaline phosphatase(ALP),total cholesterol(TC),albumin(ALB),and their impact on liver histology,as well as the incidence of adverse reactions.Results 17 studies were included for literature analysis and comprehensive evaluation.The effectiveness evaluation results showed that compared with the UDCA alone treatment group,the overall effective rate of the combined treatment group with multiple traditional Chinese medicine preparations was better;Safety evaluation results:adverse events in the treatment group and the control group were relatively mild,with no statistical significance between the two groups.Conclusion Patients with primary biliary cholangitis(PBC)should use UDCA as soon as possible for a long time,while using traditional Chinese medicine preparations in combination.Combined use of traditional Chinese medicine and western medicine can achieve better efficacy.
Combination of traditional Chinese and western medicineUrsodesoxycholic acidPrimary biliary cholangitisEfficacySafety
万方数据
维普
