Analysis of blood concentration monitoring results of sodium valproate in our hospital in 2022
Objective To analyze the monitoring results and factors of blood concentration of sodium valproate(VPA)in our hospital,and to provide reference for clinical rational drug use.Methods The clinical data on 241 patients who were monitored for blood concentration of VPA at Changshu NO.2 People's Hospital from January 2022 to December 2022 was collected and analyzed retrospectively.Chi square test or Fisher's exact test was used to analyze the effects of age,drug dosage form,and combination therapy on VPA blood drug concentration.Results A total of 438 cases of VPA were monitored in 241 patients and 58.7%of which reached the standard.Among the patients with multiple monitoring,the rate of reaching the standard has improved after adjusting the dosage.Univariate analysis showed that the VPA blood drug concentration was related to the dosage form and combination therapy(P＜0.05).Conclusion In clinical use of VPA,attention should be paid to therapeutic drug monitoring.The dose should be adjusted timely according to the monitoring results and clinical symptoms to improve clinical efficacy and reduce the adverse reactions.
万方数据
维普
