Effect of metoclopramide combined with diphenhydramine on antiemetic effect in patients with vertigo-induced vomiting
Objective To explore the effect of metoclopramide combined with diphenhydramine on the antiemetic effect in patients with vertigo induced vomiting.Methods A total of 165 patients with vertigo induced vomiting treated in 120 Emergency Branch of Beijing Huairou Hospital from June 2020 to June 2023 were selected and divided into the control group(n = 82)and the study group(n = 83)according to random number method.The control group was treated with metoclopramide,and the study group was treated with metoclopramide combined with diphenhydramine.The antiemetic effect,vertigo recovery,blood pressure,vital signs and peripheral oxygen saturation were evaluated before and after treatment in the two groups.Results There was no significant difference in the score of vertigo symptoms between the two groups before treatment(P＞0.05).After treatment,the score of vertigo symptom in the study group was significantly lower than that in the control group,with statistical significance(P＜0.05).Before treatment,there was no significant difference in SBP and DBP levels between the two groups(P＞0.05).After treatment,SBP and DBP levels in the study group were significantly lower than those in the control group,with statistical significance(P＜0.05).Before treatment,there was no significant difference in HR,RR and SpO2 levels between the two groups(P＞0.05).After treatment,HR and RR levels in the study group were significantly lower than those in the control group,and SpO2 levels were significantly higher than those in the control group,with statistical significance(P＜0.05).The total antiemetic effective rate of the study group after treatment was significantly higher than that of the control group(P＜0.05).Conclusion Compared with metoclopramide alone,metoclopramide combined with diphenhydramine can effectively improve the clinical status and vital signs of patients with vertigo induced vomiting,and reduce the occurrence of adverse reactions.
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维普
