首页|信迪利单抗联合NP方案序贯治疗对肺癌患者总生存期的影响

信迪利单抗联合NP方案序贯治疗对肺癌患者总生存期的影响

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目的 探讨信迪利单抗联合NP方案序贯治疗对肺癌患者总生存期的影响.方法 选取 2021 年 9 月~2023 年 1 月收治的肺癌患者,采用随机数字表法筛选其中 98 例患者作为研究对象,将其分为两组,对照组(49 例)采用NP方案序贯治疗,研究组(49 例)在对照组的基础上联合信迪利单抗治疗,比较两组患者的免疫功能指标水平、肿瘤标志物水平和总生存期情况.结果 治疗后,研究组患者的CD4+、CD3+及CD4+/CD8+水平较对照组更高(P<0.05);研究组患者的CEA、CYFRA21-1、CA125 水平较对照组更低(P<0.05).研究组患者的总生存率及总生存期较对照组更高(P<0.05).结论 信迪利单抗联合NP方案序贯治疗肺癌可有效延长患者生存期,使生存率得到提升,有效改善肿瘤标志物水平和免疫水平,提升生存质量.
Effect of sindilizumab combined with NP regimen on overall survival of patients with lung cancer
Objective To investigate the effect of sindilizumab combined with NP regimen on the overall survival of patients with lung cancer.Methods A total of 98 patients with lung cancer admitted to our hospital from September 2021 to Juanuary 2023 were selected by random number table method and divided into two groups:the control group(49 cases)received sequential treatment with NP regimen,and the study group(49 cases)received combined treatment with sindellizumab on the basis of the control group.The levels of immune function indexes,tumor markers and overall survival were compared between the two groups.Results After treatment,the levels of CD4+,CD3+and CD4+/CD8+in the study group were higher than those in the control group(P<0.05).After treatment,the levels of CEA,CYFRA21-1 and CA125 in the study group were lower than those in the control group(P<0.05).The overall survival rate and overall survival of the study group were higher than those of the control group(P<0.05).Conclusion Sindilizumab combined with NP regimen can effectively prolong the survival period of patients with lung cancer,improve the survival rate of patients,improve the level of tumor markers and immune indexes,and improve the quality of life of patients.

Lung cancerSindilimabNP schemeSequential treatmentOverall survival

梁晓华、邝金爱、张永杰

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开平市中心医院药剂科,广东开平 529300

肺癌 信迪利单抗 NP方案 序贯治疗 总生存期

2024

中国处方药
南方医药经济研究所

中国处方药

影响因子:0.649
ISSN:1671-945X
年,卷(期):2024.22(3)
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