摘要
目的 了解某院抗结核药物不良反应(ADR)的发生特点和规律,为临床治疗提供参考,减少ADR的发生.方法 从性别、年龄、给药途径、主要药物、ADR涉及的器官或系统及临床表现情况等角度对某院上报的 120 例抗结核药物ADR患者临床资料进行评价分析.结果 在 120 例ADR患者中,男性占比 61.67%,50 岁以上患者发生ADR的比例达到了 58.33%;静脉给药方式引起ADR占比达到了62.50%;严重程度一般的ADR占 87.50%,新的一般的ADR占 10.83%,严重的和新的严重的ADR各占 0.83%;ADR累及器官或系统最多的为皮肤及其附件、消化系统、全身性反应,引起ADR最多的药物为利福平和莫西沙星.结论 临床治疗中从预防、治疗、预后全过程保障患者生命安全;及时补充完善用药风险提示;医护人员加强ADR监测和上报.
Abstract
Objective To investigate the characteristics and regularity of adverse reactions(ADR)of anti-tuberculosis drugs in a hospital,and provide reference for clinical treatment,reduce the occurrence of ADR.Methods Evaluate and analyze the ADR data of 120 antituberculosis drug of patients in the hospital from the perspectives of gender,age,route of administration,main drugs,organs/systems involved in ADR,and clinical manifestations.Results Among 120 ADR patients,there were 74 male(61.67%).The proportion of ADR reached 58.33%in patients over 50 years old.The proportion of ADR caused by intravenous administration reached 62.50%.Mild ADR account for 87.50%,new and mild ADR account for 10.83%,severe and new severe ADRs each account for 0.83%.The most affected organs or systems in ADR are the skin and its accessories,digestive system,and systemic reactions.Rifampicin and moxifloxacin caused most ADR of all.Conclusion Ensuring patient safety from the entire process of prevention,treatment and prognosis in clinical treatment,timely supplement and improve medication risk warnings;medical staff should strengthen ADR monitoring and reporting.
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万方数据