Effect of modified Liuwei Dihuang Decoction on bone mineral density in postmenopausal women with liver and kidney yin deficiency type 2 diabetes
Objective To explore the effect of modified Liuwei Dihuang Decoction on bone mineral density of postmenopausal women with type 2 diabetes mellitus of liver and kidney yin deficiency.Methods From May 2022 to May 2023,204 postmenopausal women with type 2 diabetes mellitus with liver and kidney yin deficiency were selected and randomly divided into two groups.102 cases in the control group were treated symptomatic treatment with routine blood glucose control and calcium supplementation,while 102 cases in the observation group were treated with modified Liuwei Dihuang Decoction on the basis of the control group.Both groups were treated for 6 months.The blood glucose[glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG)],lumbar L2～4 and bone mineral density(BMD)of the left femoral neck,bone metabolism markers[total type I collagen amino terminal lengthening peptide(PINP),β-collagen special sequence(β-Crosslaps,β-CTX)],TCM syndrome score were compared between the two groups before and after treatment.Results There was no significant difference in blood glucose,bone mineral density of lumbar vertebrae and femoral neck,bone metabolism standard and TCM syndrome score between the two groups upon admission(P＞0.05).After treatment,all the indexes of patients in both groups improved(P＜0.05).After treatment,the levels of HbA1c,FPG,PINP,β-CTX and TCM syndrome score in the observation group were lower(P＜0.05),while the BMD values of lumbar L2～4 and left femoral neck bone were higher(P＜0.05).Conclusion The conventional treatment combined with modified Liuwei Dihuang Decoction can improve the TCM syndrome score,effectively control the blood glucose control,improve the bone mineral density and improve the level of bone metabolism markers in postmenopausal women with type 2 diabetes mellitus with liver and kidney yin deficiency.
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