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门诊癫痫患儿规范化诊疗疗效及预后多因素研究

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目的 本项目研究门诊癫痫患儿的诊断、治疗和疾病的转归、预后,采用回归模型对癫痫的预后进行多因素分析,探讨规范化诊疗对预后的影响。方法 在某院 2022 年 6 月~2023 年 6 月确诊的癫痫患儿中,随机抽取 84 例癫痫患儿,建立数据库,按照国际公认的标准进行规范化的诊断和治疗,要求在门诊定期复查血常规、肝肾功能、脑电图等。门诊随访后根据患者复诊及服药情况分为规范治疗组和非规范治疗组,用单因素和多因素Logistic回归分析判断癫痫患儿的预后和影响因素。结果 规范治疗组治疗总有效率高于非规范治疗组(P<0。05)。经单因素分析显示,两组在发病至规范诊疗前病程、首次脑电图是否异常放电、依从性、是否规范化诊疗等资料上出现差异(P<0。05)。将上述有差异项目代入Logistic回归方程分析得出,发病至规范诊疗前病程>1 年、首次脑电图异常放电、依从性差是规范化诊疗预后不佳的因素(OR>1,P<0。05)。结论 规范化诊疗对门诊癫痫患儿的预后起着积极的作用。而影响预后的关键因素包括发病至规范诊疗前经历的时间、首次脑电图异常放电情况以及患儿的依从性差异。
Study on standardized diagnosis and treatment effect and the prognosis multifactors for outpatient epilepsy children
Objective This project studies the diagnosis,treatment,disease outcomes and prognosis of pediatric epilepsy patients in outpatient clinics.A regression model is used to conduct a multifactor analysis of the prognosis of epilepsy,exploring the impact of standardized diagnosis and treatment on prognosis.Methods 84 children with epilepsy diagnosed in a hospital from June 2022 to June 2023 were randomly selected,a database was established and standardized diagnosis and treatment were carried out according to internationally recognized standards.Regular follow-up blood routine,liver and kidney function,EEG,etc.were required in the outpatient department.After outpatient follow-up,patients were divided into standard treatment group and non-standard treatment group based on their follow-up and medication status.Univariate analysis and multifactor Logistic regression analysis were used to determine the prognosis and influencing factors of children with epilepsy.Results The total effective rate of the standardized treatment group was higher than that of the non-standard treatment group(P<0.05).Univariate analysis showed that there were differences(P<0.05)between the two groups in terms of disease duration from onset to standardized diagnosis and treatment,whether the first EEG showed abnormal discharge,compliance and whether standardized diagnosis and treatment were performed.Substituting the above differential items into the Logistic regression equation analysis,it was found that a disease course of more than 1 year from onset to standardized diagnosis and treatment,abnormal discharge of the first EEG and poor compliance were the factors that led to poor prognosis in standardized diagnosis and treatment(OR>1,P<0.05).Conclusion Standardized diagnosis and treatment play a positive role in the prognosis of pediatric epilepsy patients in outpatient clinics.The key factors affecting prognosis include the time from onset to standardized diagnosis and treatment,abnormal discharge of the first electroencephalogram,and differences in the patient's compliance.

OutpatientEpilepsyChildrenStandardized diagnosis and treatmentPrognosisMultifactor research

张峥嵘、敖桢桢、廖翠芳、张彩红、叶秋娟

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河源市妇幼保健院,广东河源 517000

门诊 癫痫 患儿 规范化诊疗 预后 多因素研究

河源市科技计划

河科社发2922061

2024

中国处方药
南方医药经济研究所

中国处方药

影响因子:0.649
ISSN:1671-945X
年,卷(期):2024.22(4)
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