Objective Exploring the effects of Ginkgo biloba extract(GBE)on cognitive function and hippocampal inflammatory factors in sepsis associated encephalopathy(SAE)mice.Methods C57BL/6J mice were randomly divided into four groups included sham surgery group(Sham group),SAE model group(SAE group),Ginkgo biloba extract group.(GBE+SAE group),and ceftriaxone sodium group(CS+SAE group)by using random number table method,with 12 mice in each group.SAE models were established through cecal ligation and puncture(CLP).Behavioral tests including open field test,novel object recognition test,and Y-maze spontaneous alternation test were conducted on mice in each group,followed by sample collection.Immunohistochemistry was performed to assess the expression of Bax and Bcl-2 in the hippocampus,while ELISA was employed to measure the levels of TNF-α and IL-6 expression.Results SAE group mice showed cognitive impairment with increased hippocampal Bax and decreased Bcl-2 expression,alongside elevated TNF-α and IL-6 levels.GBE intervention downregulated hippocampal Bax,upregulated Bcl-2 expression,and reduced TNF-α and IL-6 levels.Conclusion GBE improves cognitive dysfunction in SAE mice,likely by inhibiting neuroinflammation and neuronal apoptosis in the hippocampus.
Ginkgo biloba extractSepsis associated encephalopathyCognitive function
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