Effects of olmesartan medoxomil combined with liraglutide injection on oxidative stress injury and urine albumin-creatinine ratio in diabetic nephropathy
Objective To analyze the effects of olmesartan medoxomil combined with liraglutide injection on oxidative stress injury and urine albumin-creatinine ratio in diabetic nephropathy.Methods A total of 80 patients with diabetic nephropathy in a hospital from July 2019 to February 2023 were selected as the study objects and divided into the control group and the observation group by random number table method,40 cases in each group.Both groups received conventional treatment,and the control group received olmesartan medoxomil on the basis of conventional treat-ment;the observation group were treated with olmesartan medoxomil combined with liraglutide injection on the basis of conventional treatment.The therapeutic effect and oxidative stress level[malondialdehyde(MDA),superoxide dismutase(SOD),total antioxidant capacity(total antioxidant capacity,T-AOC)],renal function indicators[serum creatinine(Scr),blood urea nitrogen(BUN),urinary albumin excretion rate(UAER)]and urine albumin-creatinine ratio(UACR)were compared between the two groups.Results The effective rate of the observation group was 90.00%(36/40),which was higher than 60.00%(24/40)of the control group(P＜0.05).After treatment,MDA levels were decreased in both groups,and the observation group was lower;SOD and T-TOC levels were increased in both groups,and the observation group were higher(P＜0.05);the levels of Scr,BUN,UAER and UACR in both groups were decreased after treatment,and the levels of observation group were lower(P＜0.05).Conclusion Olmesartan medoxomil combined with liraglutide injection has a good clinical effect in the treatment of diabetic nephropathy,which can alleviate oxidative stress injury,reduce urine albumin-creatinine ratio and improve renal function.
Resistance trainingLiraglutide injectionDiabetic nephropathyOxidative stress injuryUrine albumin-creatinine ratio
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