Prophylactic effect of enteral bifidobacterium supplementation combined with oropharyngeal administration of colostrum on feeding intolerance in very low birth weight infants
Objective To explore the preventive effect of enteral bifidobacterium supplementation combined with oropharyngeal administration of colostrum on feeding intolerance in very low birth weight infants.Methods 76 very low birth weight infants enrolled in a hospital from June 2021 to June 2023 were selected and divided into the control group(n=38)and the study group(n=38)according to random number method.The control group was treated with oropharyngeal administration of colostrum,the study group was treated with enteral bifidobacterium supplementation combined with oropharyngeal administration of colostrum.The prophylactic effect,growth and immunoglobulin levels of the two groups were evaluated.Results There was no significant difference in the first milk-feeding time between the two groups(P＞0.05).The number of cases of feeding intolerance(4 cases),the number of gastric retention[(1.82±0.22)times]and the amount of gastric retention[(4.50±0.45)ml]in the study group were significantly lower than those in the control group[16 cases,(3.06±0.29)times,(9.38±0.71)ml].The time to reach full intestinal feeding[(18.65±2.79)d]was lower than that of control group(21.66±2.68)d),and gastrointestinal energy intake[(564.3±22.11)kJ/kg]was higher than that of control group[(459.80±21.44)kJ/kg](P＜0.05).The time to regain birth weight in the study group[(5.41±1.20)d]was less than that in the control group[(9.58±1.54)d].The growth rates of body weight,body length and head circumference[(22.23±3.47)g/d,(0.89±0.15)cm/w,(0.60±0.09)cm/w]were higher than those of control group[(17.78±3.09)g/d,(0.76±0.11)cm/w,(0.55±0.10)cm/w](P＜0.05).After treatment,IgA,IgG and IgM in the study group[(0.012±0.003),(10.01±0.45),(0.022±0.004)g/L]were significantly higher than those in the control group[(0.006±0.002),(9.83±0.26),(0.019±0.002)g/L](P＜0.05).Conclusion Enteral bifidobacterium supplementation combined with oropharyngeal administration of colostrum has a good effect on the prevention of feeding intolerance in very low birth weight infants,and can effectively improve the level of immunoglobulin and growth rate of infants,which is worthy of popularization and application.
Very low birth weight infantsFeeding intoleranceBifidobacteriumOropharyngeal administration of colostrum
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NSTL
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