Study on the correlation between serum amino acid levels in the second trimester and gestational diabetes mellitus
Objective To investigate the relationship between serum amino acid levels in the second trimester of pregnancy and gestational diabetes mellitus(GDM).Methods A total of 48 pregnant women with GDM(GDM group)and 55 pregnant women without GDM(non-GDM group)were selected from Foshan Women and Children Hospital from January 2021 to December 2022 for cohort analysis.The basic data compar-ation of the two groups and the difference analysis of 22 amino acids were performed.Subsequently,GDM was taken as the dependent variable and differential amino acids as the independent variable for Binary Logistics regression to find out the main amino acids related to GDM.Results There was no significant difference in the baseline covariates between the two groups(P＞0.05).The levels of glutamic acid,glycine,proline,alanine,asparagine,leucine,methionine,phenylalanine,tyrosine and valine in GDM group were higher than those in non-GDM group,the differences were statistical significant(P＜0.05).Confounders were excluded by Binary Logistics regression.Elevated Ala levels emerged as an independent risk factor for GDM[OR=1.041,95%CI=(1.011,1.072),P=0.007].Conclusion The development and outcome of GDM are closely related to amino acid metabolism,and the changes of amino acid may be an important indicator for the progression and outcome of GDM.The metabolomics analysis method is expected to provide new vision and reference for the study of GDM.
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