摘要
目的 基于数据挖掘分析中风(中经络)用药规律.方法 基于中国知网、万方、维普和中国生物医学文献数据库挖掘归纳中风(中经络)相关复方,通过Excel和中医传承计算平台(V3.0)分析其用药频次、关联规则和聚类分析并研究其用药规律.结果 共计纳入108 首方,167 味中药,高频次药物有川芎、白术、当归、生黄芪和地龙等.中药功效类型以补虚类、活血化瘀类和平肝息风类为主.气味归经以温、甘、脾经为主.层次聚类分析共聚为 7 类,C1:生甘草、川芎、当归、白术、茯苓;C2:全蝎、地龙、僵蚕;C3:生黄芪、党参、红花、桃仁、生地黄、赤芍;C4:鸡血藤、延胡索、独活;C5:枸杞子、麦冬;C6:酸枣仁、泽泻、葛根、陈皮;C7:太子参、熟地黄、炙黄芪、厚朴.关联分析结果显示,川芎-红花,川芎-当归、白术是核心关联用药.结论 中风(中经络)中药用药以补虚固其本,活血化瘀治其标,平肝息风以缓其急.
Abstract
Objective Analyse the medication rules of apoplexy(middle meridian)based on data mining.Methods Stroke(middle meridians)related compounds were extracted from CNKI,Wanfang,VIP and Chinese biomedical literature database,and their drug use frequency,association rules and cluster analysis were analyzed by Excel and traditional Chinese Medicine inheritance computing platform(V3.0),and stuied the medication rules.Results A total of 108 prescriptions and 167 traditional Chinese medicines were included,and the high-frequency drugs were Chuanxiong,Atractylodes macrocephala rhizoma,Angelica sinensis,Astragalus membranaceus and earthworm,etc.The main efficacy types of traditional Chinese medicine were tonifying deficiency,promoting blood circulation and removing blood stasis,and liver calming and wind calming.The main four properties,five tastes and channel of the 167 traditional Chinese medicines were warm,sweet and spleen meridian.The hierarchical cluster analysis copolymerized 7 categories,C1:raw licorice,Chuanxiong,Angelica sinensis,Atractylodes macrocephala rhizoma,Poria cocos;C2:scorpion,earthworm,silkworm;C3:raw Astragalus,Codonopsis pilosula,safflower,peach kernel,raw rehmannia,red peony root;C4:Spatholobus suberectus,Corydalis rhizoma,Heracleum;C5:Wolfberry,ophiopogon;C6:jujube kernel,Alismatis Rhizoma,Pueraria edulis,Citri Reticulatae Pericarpium;C7:Radix pseudostellariae,cooked Rehmannia,honey-processed Astragalus,Magnolia officinalis.The results of association analysis showed that Chuanxiong-safflower,Chuanxiong-Angelica sinensis and Atractylodes macrocephala rhizoma were the core associated drugs.Conclusion Traditional Chinese medicines for the treatment of stroke(middle meridian)are used to supplement deficiency and strengthen its root,to promote blood circulation and remove stasis to treat its symptoms,and to calm liver and wind to slow its emergency.
基金项目
云南省教育厅科研项目研究生项目(2021Y486)
云南中医药大学大学生创新创业训练计划(X2021018)
NETL
NSTL
万方数据